The Vitamin D Radio

Among many other functions, the vitamin D radio (VDR) is crucial for metabolism and general homeostasis. Its damage in animals leads to alopecia and baldness. In addition , the VDR performs a critical part in the postmorphogenic hair pattern and the regulation of calcium homeostasis. It truly is found in a number of cell types, including epithelial cells, dendritic cells, macrophages, and bone tissue cells.

The VDR shows up in the center of a selection of cells, and can be important in the modulation of target gene expression inside the nucleus. In addition , the VDR may play a role for the regulation of community immune replies.

The VDR is found in various cell types, such as osteoclasts, neutrophils, keratinocytes, oligodendrocytes, epithelial cells, and resistant cells. It might be expressed inside the intestines, kidneys, and parathyroid glands.

It is important to note that the VDR has a caspase-3 site, which can be associated with a phosphorylation method that may limit its activity. It is also thought that multiple intracellular signaling paths are involved in modulating target gene expression in the nucleus.

The protein content of your VDR continues to be examined in numerous cell types, including oligodendrocytes, primary glial cultures, and glioblastoma cells. The nuclear staining with respect to VDR offers recently been confirmed in primary glial cultures, and in secondary oligodendrocyte cultures.

The protein content material of the VDR in people primary glioblastoma cells can be 220-kDa. However , the VDR-like protein is present only in a subset of these cells.

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